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Predicting Treatment Failure in HSIL Patients with Positive Margins After Conization Via Detection of PAX1 Methylation
Sponsor: Women's Hospital School Of Medicine Zhejiang University
Summary
The goal of this multicenter, observational study is to evaluate whether methylation testing of paired box gene 1 (PAX1) can better predict and diagnose recurrence or persistent disease in patients with positive margins after cervical conization for high-grade squamous intraepithelial lesion (HSIL). The main question it aims to answer is: Can PAX1 gene methylation testing provide a more accurate and effective prediction and diagnosis of cervical disease recurrence/persistence in addition to existing methods? Participants will be managed according to the latest clinical guidelines, and during follow-up, a non-invasive test, PAX1 gene methylation testing, will be added.
Official title: Multicenter Study on PAX1 Methylation for Predicting Lesion Persistence/Recurrence in HSIL Patients with Positive Margins After Cervical Conization
Key Details
Gender
FEMALE
Age Range
26 Years - 54 Years
Study Type
OBSERVATIONAL
Enrollment
800
Start Date
2024-12
Completion Date
2028-07
Last Updated
2024-12-06
Healthy Volunteers
No
Locations (1)
Women's Hospital School Of Medicine Zhejiang University
Hangzhou, Zhejiang, China