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Comparison of Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin-chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery
Sponsor: B.P. Koirala Institute of Health Sciences
Summary
Pain, edema and trismus are the most frequent postoperative sequelae to surgical removal of impacted teeth, all of are due to the local inflammatory response. Use of corticosteroids decrease tissue mediators of inflammation and reduce edema. Use of trypsin-chymotrypsin elaborates the enzymes esterase in blood plasma that inhibits inflammation by hydrolytic degradation of the inflammatory peptides.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2024-09-25
Completion Date
2025-01-25
Last Updated
2024-12-03
Healthy Volunteers
Yes
Interventions
Dexamethasone
local infiltration
Chymotrypsin
orally given
Locations (1)
Bp Koirala Institute of Health Sciences
Dharān, Koshi, Nepal