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Extracellular Vesicles in Fibrin Gel for Cartilage Repair
Sponsor: I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Summary
This project aims to produce and study in vitro/ex vivo a platelet rich plasma (PRP)-derived fibrin gel loaded with mesenchymal stromal cells (MSC)-extracellular vesicles (EVs), to combine the positive results on cartilage growth of PRP growth factors and the hyaline cartilage stimulating activity of MSC-EVs. Therefore, the project goal is to provide an advanced option for orthopedic patients with an innovative evolution of a gold standard procedure, making it easy to translate into daily clinical practice for physicians, healthcare professionals and patients.
Official title: Fibrin Gel Loaded with Extracellular Vesicles for the Treatment of Cartilage Lesions in the Joints - GelVex Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
51
Start Date
2024-10-29
Completion Date
2026-08-30
Last Updated
2024-12-03
Healthy Volunteers
No
Conditions
Locations (1)
I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Milan, MI, Italy