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Description of the Immune Response to Yellow Fever Vaccination
Sponsor: Institut Pasteur
Summary
Vaccine protection depends on a specific adaptive immune memory. However, a little-explored aspect of certain live vaccines may provide beneficial, non-specific protection against infections or pathogens other than the one from which the vaccine is derived. This is the concept of innate immune memory or " trained immunity", which differs from adaptive memory in its non-specificity. Innate immune memory is triggered by exposure to immunostimulants, and offers protection against unrelated pathogenic threats for several months or even years. The project aims to carry out an exploratory study to observe, in the context of current practice, the immune response obtained after a subunit and a live attenuated vaccine
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
38
Start Date
2024-09-30
Completion Date
2027-04-30
Last Updated
2025-06-29
Healthy Volunteers
Yes
Conditions
Interventions
blood samples collection
blood samples collected at D0 ,W1, W5, M3 and M6
Locations (1)
Centre Médical de l'Institut Pasteur
Paris, France