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DeMONSTRATE-TB Study in Ethiopia
Sponsor: Management Sciences for Health
Summary
Ending the TB epidemic by 2035 in Ethiopia would be possible if TB notification declines by an annual factor of at least 15% from the current notification rate of 132 per 100,000 population. This requires highly effective strategies to reduce TB transmission and maximize TB prevention among populations at risk of developing TB, such as Household contacts and people living with HIV. The investigators hypothesize that community wide administration of enhanced TPT will accelerate decline in TB incidence rates when combined with an optimized currently recommended comprehensive TB prevention and care packages described below. The investigators further hypothesize that such intervention packages will be acceptable to the community, providers and policy makers, and that they will be cost-effective. Based on the study results, a TB elimination framework in high burden TB regions and woredas in Ethiopia will be developed, and local evidence to enhance the shift toward TB elimination will be provided as input to the appropriate allocation of resources.
Official title: Demonstrating Multipronged and Optimized Novel Strategies to Reinforce Actions Targeted At Eliminating Tuberculosis (DeMONSTRATE-TB): a Sequential Exploratory Mixed Method Study in Ethiopia
Key Details
Gender
All
Age Range
Any - Any
Study Type
INTERVENTIONAL
Enrollment
131438
Start Date
2023-02-27
Completion Date
2025-01-01
Last Updated
2024-12-05
Healthy Volunteers
Yes
Conditions
Interventions
Enhanced community-wide TB intervention
Interventions in the intervention arms consist of the following key components: 1. an optimized national recommended set of interventions; such as the implementation of all types of contact investigation, targeted TB screening and diagnosis at key affected population, and optimized HIV screening and TPT for PLHIV; 2. intensive, active, and community-based HH screening and diagnosis of TB using combined TB screening (clinical and X-ray) and X-pert MTB/RIF, as indicated; 3. community-based enhanced TPT; and 4. community-based awareness creation and health education using the community social associations.
Routine TB program activities
In the control arm, the standard of care will continue per the national guideline.
Locations (2)
Gedebe Hassassa woreda
West Arsi Zone, Ormoia Regional State, Ethiopia
Boloso Bombe woreda
Wolayita Zone, South Ethiopia Regional State, Ethiopia