Clinical Research Directory
Browse clinical research sites, groups, and studies.
School-based Program for the Prevention of Rheumatic Heart Disease in Endemic Regions
Sponsor: Thomas Pilgrim
Summary
The overall objective of the PREVENT trial is to evaluate the effectiveness of an integrated, school-based program for the prevention of rheumatic heart disease (RHD) in regions with an endemic pattern of RHD. We conduct a stepped wedge cluster randomized trial in randomly selected schools in Nepal and Zambia. The intervention will be delivered at the level of the school and consists in the introduction of a dedicated school-nurse program providing health care through education about RHD, assessment, intervention, and follow-up of GABHS pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with RHD.
Official title: Effectiveness of an Integrated Program for the Prevention of Rheumatic Heart Disease in Endemic Regions: a Stepped Wedge Cluster Randomized Trial
Key Details
Gender
All
Age Range
5 Years - 16 Years
Study Type
INTERVENTIONAL
Enrollment
6000
Start Date
2024-12-15
Completion Date
2028-02
Last Updated
2026-01-20
Healthy Volunteers
Yes
Conditions
Interventions
School nurse program
The intervention consists in the introduction of a school-nurse program providing health care through education about rheumatic heart disease, assessment, intervention, and follow-up of group A beta-hemolytic streptococcal pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with rheumatic heart disease.
Locations (2)
National Academy od Medical Sciences
Kathmandu, Nepal
Centre of Infectious Disease Research
Lusaka, Zambia