Clinical Research Directory

Browse clinical research sites, groups, and studies.

Sites Groups Studies

Back to Studies

ACTIVE NOT RECRUITING

NCT06722339

Targeted Circuit-Based Transcranial Focused Ultrasound Intervention for Obsessive-Compulsive Disorder TUS-OCD

Sponsor: University of Plymouth

View on ClinicalTrials.gov

Summary

This study explores the potential of transcranial ultrasound stimulation (TUS) as an innovative therapeutic approach for individuals with obsessive-compulsive disorder (OCD). By targeting specific brain regions associated with compulsive behaviors and anxiety, the researchers aim to assess the safety and efficacy of TUS in reducing symptoms and enhancing cognitive flexibility.

Official title: Targeted Circuit-Based Transcranial Focused Ultrasound Intervention for Obsessive-Compulsive Disorder

Key Details

Gender

All

Age Range

21 Years - 55 Years

Study Type

INTERVENTIONAL

Enrollment

Start Date

2024-09-20

Completion Date

2026-09-20

Last Updated

2024-12-09

Healthy Volunteers

Conditions

Obsessive-Compulsive Disorder

Interventions

DEVICE

low intensity transcranial focused ultrasound stimulation (TUS)

Low-intensity transcranial focused ultrasound (TUS) provides an energy source with millimeter resolution that can be focused anywhere in the brain safely and effectively for non-invasive and transient neuromodulation. TUS is an important advance and of great significance for brain-mapping efforts, diagnostics, and therapies in neuroscience and particularly promising for addiction therapy as it provides unprecedented non-surgical access to the brain regardless of depth. Low intensities of focused ultrasound (TUS) are used so that tissue damage does not occur, but neural activity can be modulated by mechanical effects.

Inclusion Criteria will be: * Male or female, aged 21-55 years, and fluent English speaking. * Participants score ≥ 17 on the Obsessive-Compulsive Inventory-Revised (OCI-R). * Participant is willing and able to give informed consent for participation in the trial. * Participant is willing to comply with all trial requirements and committed to participating in all six testing sessions. Exclusion Criteria will be: The participant may not enter the trial if ANY of the following apply. History: * serious head trauma or brain surgery * (first-degree relatives with) epilepsy, convulsion, or seizure * diagnosis of a neurological or psychiatric disorder (other than OCD) * adverse reactions to non-invasive brain stimulation * participation in another short-term non-invasive brain stimulation study in the past 3 days * participation in another long-term non-invasive brain stimulation study in the past 28 days * recent head trauma that was diagnosed as a concussion or associated with loss of consciousness Current: * pregnancy or planning a pregnancy during the course of the trial * use of psychoactive drugs or any drugs listed in the Neurostimulation Safety Report * heart pacemaker, mechanical heart valve, mechanical implant such as an aneurysm clip, hip replacement * metal in the head or body * claustrophobia * extreme mood fluctuations * predisposition to fainting spells (syncope) * medication that will interfere with the study or constitutes an increased risk of adverse effects (e.g., affects brain excitability) * hearing problems or ringing in the ears * skin diseases or sensitivity at intended TUS stimulation site * Any significant disease or disorder which, in the opinion of the Investigator, may either put the participants at risk because of participation in the trial, or may influence the result of the trial, or the participant's ability to participate in the trial. Last 24 hours: * more than four alcoholic units * recreational psychoactive drugs * antibiotics

Locations (1)

Health

Plymouth, Devon, United Kingdom