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Treating Central Neuropathic Pain With Low Dose Naltrexone for People With Spinal Cord Injury
Sponsor: Medical College of Wisconsin
Summary
The goal of this pilot clinical trial is to find out how well low dose naltrexone works for people with pain due to spinal cord injury. The main questions it aims to answer are: will low dose naltrexone reduce pain, and increase the quality of life for people with central neuropathic pain due to spinal cord injury. Hypothesis 1: LDN will decrease the severity of CNP in adult patients with SCI as measured by the Neuropathic Pain Scale (NPS) Hypothesis 2: LDN will improve quality of life of patients with SCI as measured by various validated clinical tools There is no comparison group. This study is being completed to give investigators more information for how to best run a larger clinical trial. Participants will be asked to take an oral dose of 4.5mg of naltrexone, daily, for 12 weeks.
Official title: Low Dose Naltrexone in the Treatment of Central Neuropathic Pain After Traumatic Spinal Cord Injury: A Pilot Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2025-02-01
Completion Date
2026-12-31
Last Updated
2025-10-21
Healthy Volunteers
No
Interventions
4.5mg daily dose of naltrexone
Study subjects will take a daily 4.5mg dose of naltrexone.
Locations (1)
Medical College of Wisconsin
Milwaukee, Wisconsin, United States