Clinical Research Directory

Inclusion Criteria: Aged ≥18 with penicillin susceptible S. aureus bacteraemia (PSSA), and able to provide written informed consent. Exclusion Criteria: * allergy to penicillin, * inability to give informed consent, * concomitant growth of other clinically significant bacteria in blood cultures * neutropenia -≥ 96h with prior antibiotics * When the per oral follow up medication can not be flukloxacillin or penicillinV/Amoxicillin (ie prosthetic joint infection) * Patients in terminal palliation, where death is expected within 7 days. * Where the treating physician believes cloxacillin is not a first-line treatment.