Clinical Research Directory

Inclusion Criteria: * Patients (women or men) with histologically confirmed metastatic breast cancer * Eastern Cooperative Oncology Group (ECOG) Performance Status 0 or 1 * Written informed consent obtained prior to enrollment * Age ≥ 18 years * Blood and tumor tissue sample available for research * Measurable disease * Other site accessible for biopsy, except bone lesions if this is the only accessible site, or biopsy obtained within the previous 6 months * Medical history, blood parameters and clinical conditions do not indicate major dysfunctions of organ To treatment: \- Maintenance of screening inclusion criteria Exclusion Criteria: * Presence of visceral crisis, defined according to ABC3/ESMO guidelines * Patients with local recurrence that can be treated with surgery and/or radiotherapy alone * Patients who have previously received palliative radiotherapy on the only site accessible to biopsy * Patients with metastatic disease limited to bone * Patients with metastatic disease limited to the brain, unless planned a surgical excision, in which case tissue can be collected for screening * Severe hematopoietic, renal and/or hepatic insufficiency * Known contraindication to biopsy * Neoplastic pathology of different histology in the previous 5 years, except carcinoma in situ of cervical basal or squamous cell carcinoma of the skin, if adequately treated