Clinical Research Directory

Inclusion Criteria: * Patients of all genders, aged between 11 and 23 years old, and right-handedness. * In accordance with the diagnostic criteria for the major depressive disorder of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). * The current major depressive episode (MDE) must be confirmed using the Mini International Neuropsychiatric Interview (M.I.N.I). * Beck Depression Inventory, Second Edition (BDI-II): total BDI-II score\> 13 at screening. * Subjects who can understand and are willing to strictly follow the clinical trial protocol to complete this study and sign informed consent. Exclusion Criteria: * A diagnosis of other psychiatric disorders in the DSM-5. * Clinically significant laboratory abnormality or medical condition, that in the opinion of the investigator would hinder the subject in completing the procedures required by the study. * History of significant neurologic disease, including subdural hematoma, brain tumor, unexpected seizure/epilepsy disorder, or history of significant head trauma. * Have obvious suicide risk, or have actual suicide behavior within 6 months before the screening. * History of treatment with electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), transcranial Direct Current Stimulation (tDCS), or transcranial Alternating Current Stimulation (tACS) treatments for any disorders. * There are contraindications to magnetic resonance imaging (MRI) scanning or TMS treatment, such as metal or electronic instruments. * Participation in any investigational drug trial within 6 months before the baseline visit. * Other conditions that are not suitable for the study object in the researcher's judgment.