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Prophylactic Intravenous Injection of Neostigmine Plus Atropine Versus Ketorolac on Post-dural Puncture Headache in Patients Undergoing Infraumbilical Surgeries
Sponsor: Assiut University
Summary
Post-dural puncture headache (PDPH) or spinal (or post-spinal) headache is one of the most common side effects of spinal anesthesia, with an incidence of 6-36%. The incidence of this complication was reported to be 76-85% after accidental dural puncture in epidural anesthesia. It usually starts within several hours after spinal anesthesia, but sometimes it can be delayed for up to 2 weeks, which usually resolves within a few days
Official title: Prophylactic Intravenous Injection of Neostigmine Plus Atropine Versus Ketorolac on Post-dural Puncture Headache in Patients Undergoing Infraumbilical Surgeries: A Randomized Clinical Trial
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
330
Start Date
2024-12-15
Completion Date
2025-11-05
Last Updated
2024-12-11
Healthy Volunteers
No
Conditions
Interventions
normal Saline
patients will receive placebo (normal saline)
Neostigmine
patients will receive neostigmine (40 μg/kg) plus atropine (20 μg/kg)
Ketorolac
patients will receive ketorolac (0.5 mg/kg)
Locations (1)
Faculty of medicine, Assiut University, Assiut, Egypt,
Asyut, Egypt