Clinical Research Directory

Inclusion Criteria: * Confirmed diagnosis of HR-positive primary invasive breast cancer. Exclusion Criteria: 1. Patients if they were diagnosed with brain metastases at the time of initial breast cancer diagnosis or within the subsequent three months. 2. Bilateral breast cancer. 3. Synchronic cancer (i.e., lung cancer, melanoma). 4. Paitents presenting neurologic symptoms without follow-up or lacking a contrast-enhanced magnetic resonance image (cMRI). 5. Incomplete clinicopathological information at the time of diagnosis.