Clinical Research Directory

Inclusion Criteria: 1. Age ≥18 years old; 2. clinically diagnosed as central infection (cerebrospinal fluid culture is positive with clinical infection symptoms) or suspected as central infection (abnormal cerebrospinal fluid examination, such as hypoglycemia, \< 50%; High protein, \> 50 mg/dl; The number of cells increased with clinical infection symptoms, but no cerebrospinal fluid culture was positive) 3. receiving anti-infection treatment such as vancomycin or meropenem or linezolid or cefoperazone sulbactam; 4. Sign the informed consent form. Exclusion Criteria: 1. There is no cerebrospinal fluid to determine the concentration; 2. allergic to drugs; 3. Other factors that researchers think are not suitable for inclusion.