Clinical Research Directory

Inclusion Criteria: 1. Mechanical ventilation patients with sepsis who are expected to stay in ICU for ≥48h; 2. The condition was allowed to remain in shallow sedation (RASS-2 \~0); 3. Obtain informed consent from patients or family members Exclusion Criteria: 1. pregnancy or breastfeeding; 2. General anesthesia surgery within 48 hours; 3. Severe, pre-existing parenchymatous liver disease with clinically significant portal hypertension, Child-Pugh grade C cirrhosis or acute liver failure; 4. Patients with acute and chronic renal insufficiency requiring dialysis treatment; 5. Severe craniocerebral injury, brain tumor, increased intracranial pressure, cerebrovascular accident, coma, epileptic status, etc. 6 Medical Ethics Committee of the First Affiliated Hospital of Ningbo University; 6. Patients with a history of alcohol or drug abuse; 7. Any condition that prevents the correct assessment of cognitive function, such as speech and sensory disorders or mental disorders (language difficulties or organic mental dysfunction); 8. Failure to obtain informed consent or authorization; 9. Participate in other exploratory clinical trials within 6 months prior to screening; 10. Known or suspected allergy to the study drug.