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Heat Shock Protein 47 in Thrombosis
Sponsor: University of Aarhus
Summary
The goal of this observational study is to learn if the novel biomarker Heat shock protein 47 (HSP47) can be used as a prognostic marker for vascular disease in people with acute venous thromboembolism (VTE), myocardial infarction (AMI) or ischaemic stroke compared to healthy volunteers. The main questions it aims to answer are: 1. Are platelet levels of HSP47 higher in patients with acute VTE, AMI or stroke, compared to healthy volunteers. 2. Does platelet levels of HSP47 remain elevated in patients with acute thrombotic events compared to healthy volunteers at 3 and 12-months of follow-up. 3. Are platelet levels of HSP47 postively associated with platelet function and negatively associated with fibrinolytic capacity in patients with an acute thrombotic event. Participants with VTE, AMI or stroke will be giving a blood sample at diagnosis and again after 3 and 12 months of follow-up. Healthy volunteers will be giving a blood sample once.
Official title: Heat Shock Protein 47: A Novel Biomarker of Thrombosis Risk
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
340
Start Date
2024-12-09
Completion Date
2027-08-31
Last Updated
2025-08-21
Healthy Volunteers
Yes
Conditions
Locations (2)
Aarhus University Hospital
Aarhus, Central Region, Denmark
Deutsches Herzzentrum de Charité
Berlin, State of Berlin, Germany