Clinical Research Directory

Inclusion Criteria: 1. Fully understand and voluntarily participate in this trial, and sign the informed consent form (the informed consent form can be signed voluntarily by the participant or their legal representative); 2. A clinical diagnosis of acute ischemic stroke in the middle cerebral artery (MCA) territory; 3. National Institutes of Health Stroke Scale (NIHSS) ≥ 10 at screening; 4. A large hemispheric infarction defined as: lesion volume of 80 to 160 cm3 on magnetic resonance imaging (MRI) diffusion-weighted imaging (DWI), or computed tomography perfusion (CTP). 5. The time from onset to treatment must be ≤ 10 hours; if the onset time is unknown, treatment must be initiated within 10 hours after the time last known normal. Exclusion Criteria: 1. Theparticipant is likely to withdraw the supportive treatment on the first day; 2. There is evidence indicating a concurrent infarction in the contralateral hemisphere sufficiently serious to affect functional outcome. 3. There are clinical signs of brain herniation; CT/MRI indicates a midline shift of \>2 mm; CT/MRI indicates cerebral hemorrhage;