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Transcriptomics as an Aid in the Histological Diagnosis of Acute Rejection After Liver Transplantation
Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna
Summary
The primary objective of this exploratory study is to identify genes associated with acute rejection in liver transplant patients. To this end, a panel of acute rejection indicator genes (both humoral and cell-mediated) will be selected from results published in the literature and applied to biological material derived from biopsies. The secodnary objective is to identify genes associated with the diagnosis of humoral acute rejection and those associated with the diagnosis of cell-mediated acute rejection.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2024-10-17
Completion Date
2025-06
Last Updated
2024-12-16
Healthy Volunteers
No
Conditions
Interventions
Molecular diagnostic
RNA will be analysed using a Real-Time PCR expression card (TaqMan Real-Time PCR assay technology - Thermo Fisher Scientific). The analysis will be performed using a Real-Time Light Cycler 480 (Roche). The expression card will be customised for the study, including the genes cxcl9/10, cav-1, rhoj, cdh5, cd96, tnfsf8, il-21r, vcam, klrk1
Locations (1)
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Italy