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A Study to Investigate Multiple Sclerosis Relapse Prevention With mRNA-1195 Compared With Placebo in Participants Aged 18 to ≤55 Years
Sponsor: ModernaTX, Inc.
Summary
The primary objective of this trial is to evaluate the safety and reactogenicity of mRNA-1195 in participants with multiple sclerosis.
Official title: A Phase 2, Randomized, Observer-Blind, Placebo-Controlled, Dose-Ranging Study of mRNA-1195 Intramuscular Injection in Participants 18 to ≤55 Years of Age With Multiple Sclerosis
Key Details
Gender
All
Age Range
18 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
180
Start Date
2025-04-16
Completion Date
2029-01-08
Last Updated
2025-12-22
Healthy Volunteers
No
Conditions
Interventions
mRNA-1195
IM injection
Placebo
IM injection
Locations (17)
Boston Clinical Trials Inc - Internal Medicine
Boston, Massachusetts, United States
Quest Research Institute
Farmington Hills, Michigan, United States
Sharlin Health & Neurology
Ozark, Missouri, United States
Washington University School of Medicine Neurology Clinical Unit
St Louis, Missouri, United States
Oklahoma Medical Research Foundation (OMRF) MS Center of Excellence
Oklahoma City, Oklahoma, United States
University of Texas Southwestern Medical Center
Dallas, Texas, United States
ANESC Research
El Paso, Texas, United States
Saturn Research Solutions
Plano, Texas, United States
University of the Sunshine Coast Clinical Trials
Birtinya, Queensland, Australia
North Bristol NHS Trust - Southmead Hospital
Bristol, United Kingdom
Cardiff and Vale University Health Board - University Hospital Wales
Cardiff, United Kingdom
Anne Rowling Regenerative Neurology Clinic, University of Edinburgh
Edinburgh, United Kingdom
NHS Greater Glasgow & Clyde - Institute of Neurological Sciences
Glasgow, United Kingdom
Cambridge Clinical Research Centre
London, United Kingdom
East Kent Hospitals University NHS Foundation Trust
London, United Kingdom
The Newcastle Upon Tyne Hospitals NHS Foundation Trust
Newcastle upon Tyne, United Kingdom
Sheffield Teaching Hospital NHS foundation Trust, Herries Road
Sheffield, United Kingdom