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RECRUITING
NCT06735248
PHASE2

A Study to Investigate Multiple Sclerosis Relapse Prevention With mRNA-1195 Compared With Placebo in Participants Aged 18 to ≤55 Years

Sponsor: ModernaTX, Inc.

View on ClinicalTrials.gov

Summary

The primary objective of this trial is to evaluate the safety and reactogenicity of mRNA-1195 in participants with multiple sclerosis.

Official title: A Phase 2, Randomized, Observer-Blind, Placebo-Controlled, Dose-Ranging Study of mRNA-1195 Intramuscular Injection in Participants 18 to ≤55 Years of Age With Multiple Sclerosis

Key Details

Gender

All

Age Range

18 Years - 55 Years

Study Type

INTERVENTIONAL

Enrollment

180

Start Date

2025-04-16

Completion Date

2029-01-08

Last Updated

2025-12-22

Healthy Volunteers

No

Interventions

BIOLOGICAL

mRNA-1195

IM injection

BIOLOGICAL

Placebo

IM injection

Locations (17)

Boston Clinical Trials Inc - Internal Medicine

Boston, Massachusetts, United States

Quest Research Institute

Farmington Hills, Michigan, United States

Sharlin Health & Neurology

Ozark, Missouri, United States

Washington University School of Medicine Neurology Clinical Unit

St Louis, Missouri, United States

Oklahoma Medical Research Foundation (OMRF) MS Center of Excellence

Oklahoma City, Oklahoma, United States

University of Texas Southwestern Medical Center

Dallas, Texas, United States

ANESC Research

El Paso, Texas, United States

Saturn Research Solutions

Plano, Texas, United States

University of the Sunshine Coast Clinical Trials

Birtinya, Queensland, Australia

North Bristol NHS Trust - Southmead Hospital

Bristol, United Kingdom

Cardiff and Vale University Health Board - University Hospital Wales

Cardiff, United Kingdom

Anne Rowling Regenerative Neurology Clinic, University of Edinburgh

Edinburgh, United Kingdom

NHS Greater Glasgow & Clyde - Institute of Neurological Sciences

Glasgow, United Kingdom

Cambridge Clinical Research Centre

London, United Kingdom

East Kent Hospitals University NHS Foundation Trust

London, United Kingdom

The Newcastle Upon Tyne Hospitals NHS Foundation Trust

Newcastle upon Tyne, United Kingdom

Sheffield Teaching Hospital NHS foundation Trust, Herries Road

Sheffield, United Kingdom