Clinical Research Directory

Participant Inclusion Criteria, Candidates for this study must meet ALL the following inclusion criteria: 1. Patient is between 18 and 65 years of age (inclusive) at the time of consent. 2. Age of onset of Chronic Migraine ≤ 64 years. 3. Age of onset of migraine diagnosis \< 50 years. 4. Patient has a current diagnosis of refractory migraine. 5. Patient has a current diagnosis of Chronic migraine. Participant Exclusion Criteria, Candidates will be excluded from participation if ANY of the following apply: 1\. Patients with a history for the last 2 years of other types of headache. 2. Patients with diagnosis of hemiplegic migraine or migrainous infarct. 5. Patients with current regular use of Opioids, Cannabis, Medical Marijuana, etc. 6\. Women who are pregnant, lactating, or who are of childbearing age. 7. Current involvement in an investigational (drug, device, etc.) clinical trial that may confound study endpoints. Patients in observational, natural history, and/or epidemiological studies not involving intervention are eligible. Sponsor approval is required.