Clinical Research Directory

Inclusion Criteria: 1. Age is 18 years old or older 2. Written consent to participate in the study 3. All subjects must be candidates to undergo percutaneous peripheral or coronary diagnostic or interventional procedures where use of a Guide Wire is indicated. 4. Eligible for catheter-based diagnostic or treatment procedure. A representative list of diseases and catheter-based treatments includes: Suspicion of obstructive coronary artery disease manifest as myocardial infarction, angina pectoris, angina-equivalent, ischemic dysrhythmia, or evidence of ischemia or viability on non-invasive cardiovascular testing Suspicion of peripheral vascular obstructive disease undergoing elective or urgent diagnostic and/or percutaneous therapeutic procedures. 5. Palpable pulse of the proximal and distal radial artery on one or both arms 6. Subjects must be suitable for a transfemoral vascular access 7. Subjects undergoing elective or urgent percutaneous treatment of symptomatic arterial occlusive disease and intermittent claudication or CLI of the SFA and/or popliteal arteries. 8. Subjects with suspected narrowed or blocked arteries in the heart. Exclusion Criteria: 1. Inability to provide consent 2. Pregnant or lactating women 3. Subjects actively participating in another drug or device investigational study and have not yet completed the primary endpoint follow-up period. 4. Subjects with bilateral hand or arm misalignment / paresis that makes a radial access impossible 5. Subject has a known allergy to the Guide Wire materials 6. Subjects with emergent procedures acute ischemia, aneurysmal disease, common femoral or profunda interventions, or hybrid procedures were excluded. 7. Subjects with severe infections 8. Subjects with severe heart failure 9. Subjects with severe physical weakness