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Efficacy and Safety of Tamsulosin for Children with Posterior Urethral Valve.
Sponsor: Mansoura University
Summary
To determine whether there is a role for Tamsulosin, A Selective Alpha-1 Adrenergic Blocker, as therapy in children with Posterior Urethral Valve post valve ablation , and whether there are side effects involved.
Official title: Efficacy and Safety of Tamsulosin, a Selective Alpha-1 Adrenergic Blocker, for Children with Posterior Urethral Valve: a Randomized Controlled Trial
Key Details
Gender
MALE
Age Range
Any - 12 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2024-11-01
Completion Date
2026-11
Last Updated
2024-12-20
Healthy Volunteers
No
Conditions
Interventions
Tamsulosin
Children will be maintained on an oral dose of Tamsulosin 0.1 mg once daily (in children aged less than 2 years old) and 0.2 mg once daily (≥2 years old).
Oxybutynin
Children will be maintained on an oral dose of Oxybutynin 0.2 mg/kg 2 times daily.
Trimethoprim/sulfamethoxazole (TMP/SMZ)
Children will be maintained on an oral prophylactic dose of Trimethoprim/sulfamethoxazole 2 mg/kg single dose at night.
Locations (1)
Mansoura Urology and Nephrology Center
Al Mansurah, Dakahlia Governorate, Egypt