Clinical Research Directory

Inclusion Criteria: * aged 18 to 38 years (age limits based on evidence of delayed wound healing in older adults, Engeland et al., 2006); * full-mouth plaque score and full-mouth bleeding score ≤ 15% at study entry; * adequate anteroposterior arch length for required wound size and spacing; * able to easily tolerate maxillary impression making and use of palatal template; * patients required at least two root coverages procedures in one tooth in different sextants with DFGG; * palate with no pathological or morphological alteration. Exclusion Criteria: * untreated periodontitis; * previous surgery on the palate; * history of poor wound healing; * systemic diseases and/or coagulations disorders; * pregnant or lactating; * smoking or marijuana use (non-smoker status verified by exhaled air carbon monoxide as previously described); * medications affecting periodontal status (e.g. phenytoin, calcium channel blockers and cyclosporine); * therapy with anticoagulants, nonsteroidal anti-inflammatory drugs, corticosteroids, or any drug interfering with the healing process during the previous six months; * contraindication to receiving any of the active components of the antimicrobial gel.