Clinical Research Directory

Inclusion Criteria: * More than 20 natural teeth excluding the third molars * Clinical indication for a surgical intervention for the treatment of at least one residual pocket after non-surgical therapy (pocket depth (PD) ≥5mm) * Have a full mouth plaque score (FMPS) \<15% before surgery; * Have a full mouth bleeding score (FMBS) \<15% before surgery; * Ability and willingness to give written informed consent; * Written agreement to participate in the trial. Exclusion Criteria: * Use of medications, such as anti-platelet or anti-coagulant agents, any other concomitant systemic disorder, cardiovascular and diabetes diseases, allergic, infectious diseases and medications affecting periodontal inflammation * Pregnancy or breastfeeding; * Use of medication affecting the healing process; * Assumption of systemic or local antibiotics in the 4 weeks before trial beginning; * Conditions of the teeth or of the site that contraindicate the surgery (severe mobility, fractures, untreated endodontic lesions, incongruous restorations); * Patients with previous periodontal treatment or who were undergoing a course of dental or orthodontic treatment will be also excluded. * Tobacco use (10 or more cigarettes per day) * Inability to comply with protocol * Uncooperative patient