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Total-body Glucose Utilization in Obesity
Sponsor: Turku University Hospital
Summary
There are three goals for this study. One is to investigate how different emotions and exposure to cold affect blood flow in the body. The second aim is to study how insulin affects blood flow and tissue glucose uptake, and to study whether this effect is altered in obesity. Last, the study focuses on establishing the lowest dose of a PET radiotracer, oxygen-15 labelled water, that can be used in clinical studies with a new whole-body PET scanner.
Key Details
Gender
All
Age Range
20 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2023-01-25
Completion Date
2024-12
Last Updated
2024-12-18
Healthy Volunteers
Yes
Conditions
Interventions
Movies
Participants will watch eight short movie clips, and the changes different emotions evoked by the clips will be studied using H2\[15O\]O PET/CT.
Cold
Participants will be studied with H2\[15O\]O PET/CT while one of their legs will be exposed to cold to study the effects of cold stimulus on whole-body blood flow.
Hyperinsulinemic euglycemic clamp
Participants will be administered intravenous fast acting insulin (NovoRapid, Novo Nordisk, 1 mU/m2 body surface area/min) together with 20 % glucose to maintain normal glucose values (5.0 mmol/L) to study the effects of insulin on whole body blood flow with H2\[15O\]O PET/CT, and to assess tissue insulin-stimulated glucose uptake with \[18F\]FDG PET/CT.
H2[15O]O PET/CT
H2\[15O\]O PET/CT, with a dose of 25-700 MB/bolus repeated 2-8 times per scan.
[18F]FDG PET/CT
Whole-body \[18F\]FDG PET/CT scan to study tissue glucose uptake, dose 100 MBq
CEUS or Contrast enhanced Ultrasound
Contrast-enhanced ultrasound of left forearm muscles is performed during fasting and after 30-40 minutes of hyperinsulinemia
Locations (1)
Turku PET Centre
Turku, Finland