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Pulsed Field Ablation in Three Different Substrate Ablation Strategies for Persistent Atrial Fibrillation
Sponsor: Shanghai Chest Hospital
Summary
This multicenter, randomized, controlled trial aims to evaluate the efficacy and safety of pulsed field ablation (PFA) in patients with persistent atrial fibrillation (PeAF). We will compare three distinct substrate ablation strategies: anatomical guided ablation (ANAT group), electrogram guided ablation (EGM group), and extensive electro-anatomical guided ablation (EXT group). The study seeks to identify which ablation strategy yields the highest efficacy and safety profiles to potentially guide future clinical practice in the management of PeAF.
Official title: Efficacy and Safety of Pulsed Field Ablation in Three Different Substrate Ablation Strategies for Persistent Atrial Fibrillation: a Multicenter Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
600
Start Date
2024-12-25
Completion Date
2026-12-01
Last Updated
2024-12-18
Healthy Volunteers
No
Conditions
Interventions
Extensive Electro-Anatomical Guided Ablation
Ablation using PFA. Combination of anatomical and electrogram-guided ablation techniques.
Anatomical Guided Ablation
Ablation using PFA. Guided by anatomical landmarks without potential mapping
Electrogram Guided Ablation
Ablation using PFA. Guided by real-time electrogram characteristics from a multi-electrode catheter.
Locations (1)
No. 241, West Huaihai Road
Shanghai, Shanghai Municipality, China