Clinical Research Directory

Inclusion Criteria: 1. Age 18-80 years; 2. Patients with moderate to severe ARDS on mechanical ventilation Exclusion Criteria: 1. Patients with severe asthma or acute exacerbation of chronic obstructive pulmonary disease (COPD), lung tumors, post-lung resection, and post-lung transplantation. 2. Patients with hemodynamic instability requiring vasopressor support: dopamine or dobutamine \>15 µg/kg/min, norepinephrine \>0.3 µg/kg/min. 3. Cardiogenic pulmonary edema. 4. Patients with severe facial deformities, facial trauma, or severe thoracoabdominal trauma that precludes prone positioning ventilation. 5. Mid to late pregnancy. 6. Patients with a history of malignancy or other irreversible diseases/conditions, including those in the terminal stage. 7. Patients expected to be discharged soon or requiring invasive mechanical ventilation for less than 24 hours. 8. Patients currently participating in other studies.