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Trial in Arrhythmia Radioablation for Ventricular Tachycardia: Single Fraction vs Three Fractions
Sponsor: Weill Medical College of Cornell University
Summary
This is a research study that aims to understand if giving a lower dose of treatment all at once is as effective and safe as dividing it into three smaller doses for patients with a heart condition called refractory ventricular tachycardia (VT). These patients have not exhibited positive responses to conventional medications or procedures. This study aims to explore whether an alternative approach could yield more beneficial outcomes.
Official title: Dose De-escalation Randomized Phase I/II Trial in Arrhythmia Radioablation for Ventricular Tachycardia: Single Fraction vs Three Fractions
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2024-12-18
Completion Date
2030-12
Last Updated
2026-01-26
Healthy Volunteers
No
Conditions
Interventions
Radiation Therapy
Group 1 (3 participants) - will receive a dose of 20 Gy ("Gray", a measurement of radiation) in a single study intervention (one study intervention day)
Radiation Therapy
Group 2 (3 participants) - will receive a dose of 15 Gy in a single study intervention (one study intervention day)
Radiation Therapy
Group 3 (3 participants) - will receive a dose of 10 Gy in a single study intervention (one study intervention day)
Radiation Therapy
Group 1 (3 participants) - will receive a dose of 12 Gy given over 3 days (Days 1, 2 and 3). (Total radiation dose = 36Gy)
Radiation Therapy
Group 2 (3 participants) - will receive a dose of 10 Gy given over 3 days (Days 1, 2 and 3). (Total radiation dose = 30Gy)
Radiation Therapy
Group 3 (3 participants) - will receive a dose of 8 Gy given over 3 days (Days 1, 2 and 3). (Total radiation dose = 24Gy)
Locations (1)
Weill Cornell Medicine
New York, New York, United States