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Carotid Sinus Massage in Trendelenburg Position for Headache Relief
Sponsor: Hospital Municipal Pedro T. Orellana
Summary
Headaches significantly impact patients' quality of life, with tension-type headaches and migraines being among the most prevalent types. There is growing evidence suggesting that blood pressure regulation and baroreceptor activity play a role in headache pathophysiology. Carotid sinus massage (CSM), particularly when combined with the modified Trendelenburg position, may modulate autonomic nervous system activity to relieve headache symptoms. An initial open-label pilot study (n = 17) was completed, and the results were published in a preprint server for health sciences, the Medical Research Archive (medRxiv), demonstrating the feasibility, safety, and promising preliminary efficacy of CSM+T. Based on these findings, a follow-up randomized, sham-controlled, parallel-arm trial will further evaluate the efficacy of the treatment.
Official title: Effectiveness of Carotid Sinus Massage in Modified Trendelenburg Position for Acute Headache Episodes: A Pilot Study
Key Details
Gender
All
Age Range
16 Years - Any
Study Type
INTERVENTIONAL
Enrollment
18
Start Date
2024-12-21
Completion Date
2025-12-30
Last Updated
2025-06-15
Healthy Volunteers
No
Conditions
Interventions
Arm A - Carotid Sinus Massage + Trendelenburg (CSM+T)
Manual stimulation of the carotid sinus area combined with head-down tilt positioning to activate baroreceptors for headache relief.
Arm B - Sham CSM+T
Light neck contact, avoiding carotid sinus pressure, paired with identical body positioning to mimic the experimental intervention.
Locations (1)
Hospital Pedro T.Orellana, Trenque Lauquen
Trenque Lauquen, Buenos Aires, Argentina