Clinical Research Directory

Inclusion Criteria: * Age 18 years and older * Patients diagnosed with metastatic spinal tumors with one index metastatic site that, confirmed by the treating clinicians, is causing spine pain * Patients experience at least one type of pain that is of interest of this study, namely, axial non-triggered pain, axial triggered/mechanical pain, radicular non-triggered pain, and radicular triggered/mechanical pain * At least one type of the pain experienced has an NRS \> 4 of 10 * Patients undergoing surgery and/or radiotherapy * Surgery may be instrumented stabilization surgery alone, instrumented stabilization and decompression, or decompression surgery alone. * Percutaneous screw fixation counts as instrumented stabilization surgery. * Any kind of radiotherapy is includable. * Ability to provide informed consent according to the IRB/EC defined and approved procedures Exclusion Criteria: * Estimated survival \< 3 months * Patients with more than one symptomatic spine metastasis site o An example is a patient with two metastasis sites: a lumbar metastasis (causing vertebral fracture and epidural compression leading to mechanical lower back pain and static radicular pain to legs) and a cervical metastasis (causing tumor-related pain at the neck). * Patients with other sources of pain that may confound the measurement of the primary outcome o An example is a patient with liver metastasis which causes visceral pain that can confound the thoracic spinal pain caused by the spinal metastasis. * Patients undergoing the following treatments alone without the surgeries listed in the inclusion criteria or radiotherapy * Cement augmentation, vertebroplasty, kyphoplasty, and other emerging interventions such as local ablative technique * Chemotherapy or systemic therapy alone