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Methamphetamine Isomer Pharmacology in Humans
Sponsor: University of Wisconsin, Madison
Summary
This study is being done to understand the metabolism and impairment profile of methamphetamine (meth). Meth exists as two chemical structures that are mirror images of each other: R-meth and S-meth. S-meth is a strong central nervous system stimulant and used to treat attention deficit disorder (ADD). R-meth is not a strong central nervous system stimulant and is available over-the-counter in nasal decongestant sprays.17 healthy participants will be enrolled for 3 study visits and on study for up to 12 weeks.
Official title: The Low-Down on Methamphetamine Isomers: Prevalence and Pharmacology in Humans
Key Details
Gender
All
Age Range
21 Years - 64 Years
Study Type
INTERVENTIONAL
Enrollment
17
Start Date
2026-04
Completion Date
2028-03
Last Updated
2026-03-25
Healthy Volunteers
Yes
Conditions
Interventions
S-(+)-methamphetamine
15 mg
R-(-)-methamphetamine
15 mg
1:1 racemic mixture of two isomers
15 mg R-Meth + 15 mg S-Meth
Locations (1)
University of Wisconsin
Madison, Wisconsin, United States