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NOT YET RECRUITING
NCT06746831
PHASE1

Methamphetamine Isomer Pharmacology in Humans

Sponsor: University of Wisconsin, Madison

View on ClinicalTrials.gov

Summary

This study is being done to understand the metabolism and impairment profile of methamphetamine (meth). Meth exists as two chemical structures that are mirror images of each other: R-meth and S-meth. S-meth is a strong central nervous system stimulant and used to treat attention deficit disorder (ADD). R-meth is not a strong central nervous system stimulant and is available over-the-counter in nasal decongestant sprays.17 healthy participants will be enrolled for 3 study visits and on study for up to 12 weeks.

Official title: The Low-Down on Methamphetamine Isomers: Prevalence and Pharmacology in Humans

Key Details

Gender

All

Age Range

21 Years - 64 Years

Study Type

INTERVENTIONAL

Enrollment

17

Start Date

2026-04

Completion Date

2028-03

Last Updated

2026-03-25

Healthy Volunteers

Yes

Conditions

Interventions

DRUG

S-(+)-methamphetamine

15 mg

DRUG

R-(-)-methamphetamine

15 mg

DRUG

1:1 racemic mixture of two isomers

15 mg R-Meth + 15 mg S-Meth

Locations (1)

University of Wisconsin

Madison, Wisconsin, United States