Clinical Research Directory

Inclusion Criteria: In order to be eligible to participate in this study, an individual must meet all of the following criteria: * Male or female, aged between 45 and 95 years. * Cohort 1: Presence of cognitive complaints and objectively measured cognitive impairment of an MMSE of \> 26, such as memory loss or other cognitive difficulties (60% of the overall study population). These complaints can be self-reported or noted by a close family member. Diagnosis of MCI by PI or delegated qualified provider on the study team. * Cohort 2: Absence of cognitive complaints and absence of objectively measured cognitive impairment as determined by MMSE \> 26 and neuropsychological tests. Diagnosis of CN by PI or delegated qualified provider on the study team (40% of the overall study population). * Willing to sign written informed consent and ability to comply with study requirements. * Have adequate vision and hearing, with or without corrective devices, to ensure accurate self-reporting and comprehension of study materials. Exclusion Criteria: An individual who meets any of the following criteria will be excluded from participation in this study: * Participants with dementia, defined here as an MMSE of \< 25 and diagnosis of cognitive decline that is not MCI but more severe in nature by the PI or delegated qualified provider on the study team. * Advanced, severe progressive or unstable disease that may interfere with the safety, tolerability and study assessments, or put the participant at special risk as judged by the investigator. * Subjects who had received an investigational drug or therapy within 30 days or 5 half-lives, whichever was longer, of the first visit. * Participants with glaucoma, cataract, macular degeneration in both eyes, or any other cause of uncorrected visual impairment (less than 20/30). * Participants with severe color-blindness. * Participants with developmental cognitive dysfunction (congenital, pediatric). * Major psychiatric disorder (e.g., chronic psychosis, recurrent depressive disorder, generalized anxiety disorder). * Use of cognitive enhancing drugs (e.g., cholinesterase inhibitors). * A concurrent diagnosis of epilepsy. * History of alcohol misuse and/or illicit drug use. * History of acute damage, including stroke, traumatic brain injury, tumors, etc. * Presence of sleep apnea. * Recent participation in another neuropsychological study.