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Research on Circulation Management Strategy Based on Oxygen Metabolism Balance After CHD Surgery
Sponsor: Children's Hospital of Fudan University
Summary
The objective is to investigate a goal-oriented postoperative circulation management strategy centered on "oxygen metabolism balance". This strategy is independent of the absolute metrics of oxygen supply and consumption, and aims to enhance oxygen consumption and uptake within the critical "golden 8 hours" following pediatric cardiopulmonary bypass, thereby preventing severe hypotension, cardiopulmonary arrest, and other adverse events.
Official title: Research on Circulation Management Strategy Based on Oxygen Metabolism Balance After Congenital Heart Disease Surgery
Key Details
Gender
All
Age Range
1 Week - 18 Years
Study Type
INTERVENTIONAL
Enrollment
300
Start Date
2025-01-01
Completion Date
2027-12-31
Last Updated
2026-03-16
Healthy Volunteers
No
Conditions
Interventions
"goal-directed" treatment strategy based on oxygen supply and consumption balance
The oxygen extraction rate immediately after CPB is set as E1, the oxygen extraction rate at 4 hours after surgery is E2, and the oxygen extraction rate at 8 hours after surgery is E3. A "goal-directed" treatment strategy based on oxygen supply and consumption balance is defined as: Combined with the value of E2 at 4 hours after CPB, the increasing oxygen consumption (VO2) after CPB is compensated by increasing oxygen delivery (DO2) to different degrees. The goal of E3 not increasing significantly compared with E1 is achieved at 8 hours after CPB, and the severity of low cardiac output is finally reduced within the "golden 8 hours" after CPB.
Conventional Treatment group
Ventilation support is adjusted to maintain arterial oxygen partial pressure and oxygen saturation. Appropriate fluid infusion to stabilize central venous pressure and ensure preload; Combined use of vasoactive drugs to maintain heart rate and blood pressure; Appropriate diuresis can improve urine output and reduce cardiac afterload. Blood transfusion is used to improve coagulation function and maintain appropriate hematocrit.
Locations (1)
Children's Hospital of Fudan University
Minhang, Shanghai Municipality, China