Clinical Research Directory

Inclusion Criteria: 1. Males and females between 40 to 65 years of age. 2. Individuals with no significant history of inflammatory bowel disease (i.e. ulcerative colitis, Crohn's, Celiac, etc.), ulcers, liver and/or kidney disease or other any acute or chronic dis-ease. 3. Ability to read and speak English 4. Subject's agreement to voluntarily participate in the study 5. Negative pregnancy test confirmed with serum HCG on initial baseline testing and baseline testing at the start of the crossover (at 10 weeks) Exclusion Criteria: 1. Males and females under 40 or over 65 years of age 2. Previous (in the past 60 days) or current hormone replacement therapy 3. Males and females with free testosterone levels over normal range 4. History of hysterectomy, oophorectomy, or orchiectomy 5. Current biotin supplementation \>3 mg per day one week prior to the start of the study 6. Current or history of smoking 7. CoQ10/Ubiquinol supplementation within the past 2 weeks 8. Current use of hormone boosting supplements (i.e. fenugreek, shilajit, tongkat ali, ashwagandha) within the past 4 weeks 9. Current or previous use of medication - NSAIDS, statins, blood thinners, H2 blockers and PPI or blood sugar-lowering agents. 10. Diabetes 11. Cancer 12. Hemophilia 13. Disorders of heart, kidney, lung or liver function 14. Infectious diseases 15. Alcohol or drug abuse (\>7 drinks per week for men and women) 16. Pregnancy, lactation, or individuals planning to become pregnant in the next 6 months 17. Failure to submit statement of consent 18. Participant in a clinical trial in the previous 30 days.