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Effect of High Protein Diet on Hepatic Steatosis in Patients With MAFLD
Sponsor: Institute of Liver and Biliary Sciences, India
Summary
MAFLD is a growing problem in India. Its pathophysiology is complex, but focused on abnormal substrate handling due to mitochondrial dysfunction reflecting as metabolic inflexibility. Nutrition is the cornerstone of management. The ideal macronutrient distribution within a hypocaloric diet is not known yet. Evidence from experimental and a few human studies in obese, highlight the role of dietary proteins, independent of calorie restriction, in reducing hepatic steatosis by improving the cellular and systemic bioenergetics.
Official title: Effect of High Protein Diet on Hepatic Steatosis, Inflammation and Mitochondrial Bioenergetics in Patients With MAFLD : A Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
140
Start Date
2024-12-27
Completion Date
2027-05-01
Last Updated
2024-12-27
Healthy Volunteers
No
Interventions
High protein diet
High protein diet
Normal Protein diet
Normal protein diet
Locations (1)
Institute of Liver and Biliary Sciences
Delhi, New Delhi, India