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Exploring the Modulatory Role of Brain State on the Prefrontal Response to Excitatory Stimulation
Sponsor: The Hong Kong Polytechnic University
Summary
Therapeutic repetitive transcranial magnetic stimulation (rTMS) for depression is well-supported, with multiple protocols approved by the United States Food and Drug Administration and global efforts aimed at boosting its antidepressant effects underway. However, there exists an under-reported aspect of clinical trials using rTMS: what are patients doing during each stimulation session? Here, the investigators begin this investigation with individuals without a history of depression nor other psychiatric diagnosis. The investigators focus on the underlying brain activity. The investigators will systematically assess the modulatory role of brain state on the brain's response to a session of rTMS by using a concurrent, non-invasive brain imaging setting: functional near-infrared spectroscopy (fNIRS), marking the first effort of its kind in this field.
Official title: Systematic Assessment of the Modulatory Role of Brain State on the Prefrontal Response to Excitatory Stimulation: a Concurrent RTMS/fNIRS Pilot Study
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
36
Start Date
2024-12-03
Completion Date
2025-09-01
Last Updated
2025-03-20
Healthy Volunteers
Yes
Conditions
Interventions
intermittent theta-burst stimulation (iTBS)
In each visit, the intensity of the iTBS applied to the participant will be set at 70% of their individual resting motor threshold (rMT), with one session specifically targeting the left DLPFC.
Locations (1)
The Hong Kong Polytechnic University
Kowloon, Hong Kong