Clinical Research Directory

Key Inclusion Criteria: * The patient's disease is serious or life-threatening. * The patient has undergone appropriate standard treatments; there are no comparable or satisfactory alternative treatments for the disease or condition; the treatment is adjunct to an existing treatment option, and the treatment is not medically contra-indicated. * Sufficient efficacy and safety evidence exists to make a benefit-risk analysis consistent with this policy and the potential patient benefit justifies any potential risks of treatment. * Sufficient clinical data are available to identify an appropriate dose and treatment duration. * The patient's treating physician and qualified medical personnel at Agenus agree there is sufficient evidence to assume the potential benefit to the patient justifies potential risks. * The patient is not eligible for participation in an ongoing clinical trial of the investigational medicine, including lack of access due to geographic limitations. * Expanded Access will not adversely impact any clinical development program, in particular, the conduct of a pivotal clinical trial that is required for regulatory approval. * The request must be made by the patient's treating physician. Note: Other defined Inclusion/Exclusion criteria may apply.