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RECRUITING
NCT06752018

Inflammation's Impact on Heart Disease and Diabetes

Sponsor: University of Aarhus

View on ClinicalTrials.gov

Summary

The goal of this observational study is to evaluate the inflammatory response associated with cardiometabolic diseases, and whether these can be reduced by ex vivo treatment with therapeutic agents. Briefly, the study involves two populations: healthy volunteers and severely obese patients undergoing weight-loss surgery. The main questions the study seeks to address are: 1. To investigate if the therapeutic agents modulate the inflammatory response linked to obesity and cardiometabolic disease? 2. What underlying factors contribute to variations in individual responses? Researchers will examine differences between healthy participants and those undergoing weight-loss surgery to assess the potential impact of weight loss on responsiveness and overall outcomes. Participants will: * Undergo initial testing to evaluate their baseline response. * Provide samples during surgery for further analysis. * Participate in follow-up assessments to track changes over time.

Official title: Inflammation: a Key Contributor to Heart Disease and Diabetes?

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

250

Start Date

2025-01-30

Completion Date

2030-12

Last Updated

2025-02-03

Healthy Volunteers

Yes

Interventions

PROCEDURE

Gastric bypass

Roux-en-Y gastric bypass or sleeve gastrectomy

Locations (1)

Steno Diabetes Center Aarhus

Aarhus, Denmark