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Inflammation's Impact on Heart Disease and Diabetes
Sponsor: University of Aarhus
Summary
The goal of this observational study is to evaluate the inflammatory response associated with cardiometabolic diseases, and whether these can be reduced by ex vivo treatment with therapeutic agents. Briefly, the study involves two populations: healthy volunteers and severely obese patients undergoing weight-loss surgery. The main questions the study seeks to address are: 1. To investigate if the therapeutic agents modulate the inflammatory response linked to obesity and cardiometabolic disease? 2. What underlying factors contribute to variations in individual responses? Researchers will examine differences between healthy participants and those undergoing weight-loss surgery to assess the potential impact of weight loss on responsiveness and overall outcomes. Participants will: * Undergo initial testing to evaluate their baseline response. * Provide samples during surgery for further analysis. * Participate in follow-up assessments to track changes over time.
Official title: Inflammation: a Key Contributor to Heart Disease and Diabetes?
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
250
Start Date
2025-01-30
Completion Date
2030-12
Last Updated
2025-02-03
Healthy Volunteers
Yes
Interventions
Gastric bypass
Roux-en-Y gastric bypass or sleeve gastrectomy
Locations (1)
Steno Diabetes Center Aarhus
Aarhus, Denmark