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rTMS Combined With Motor Training for the Treatment of Upper Limb Motor Dysfunction in Stroke Patients
Sponsor: Ruijin Hospital
Summary
The goal of this clinical trials is to investigate the effectiveness of online repetitive transcranial magnetic stimulation (rTMS) in enhancing upper limb motor rehabilitation during the subacute and chronic phase of stroke. It will also learn about the safety of online rTMS intervention methods. The main questions it aims to answer are: 1. Does rTMS combined with motor training improve motor rehabilitation in patients？ 2. Does repetitive transcranial magnetic stimulation (rTMS) combined with motor training enhance the upper limb motor rehabilitation ability in stroke patients by strengthening the functional coupling of the motor circuit to achieve functional reorganization of the brain network ? Researchers will compare online rTMS to offline and sham stimulation in stroke patients to see if online rTMS works to alleviate motor dysfunction in multicenter multicenter, blinded and controlled trial. Participants will: 1. randomized to one group(online, offline or sham); 2. receive rTMS treatment for 10 days, with 5 working days per week for a total of two weeks; 3. receive magnetic resonance imaging (MRI) and electroencephalogram (EEG) evaluations before and after the entire treatment; 4. conduct scales and MEP assessment one day before the treatment, as well as one day, one month, and three months after the treatment.
Official title: Individualized rTMS Concurrent With Motor Actions Promotes Post-stroke Upper Limb Recovery
Key Details
Gender
All
Age Range
20 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2023-02-20
Completion Date
2025-12
Last Updated
2025-12-04
Healthy Volunteers
No
Conditions
Interventions
Online stimulation
5 Hz rTMS is applied to the primary motor cortex on the affected hemisphere when the patients are performing motor tasks.
Offline stimulation
After 5 Hz rTMS is applied to the primary motor cortex on the affected hemisphere, the patients perform motor tasks.
Sham stimulation
Sham rTMS is applied to the primary motor cortex on the affected hemisphere when the patients are performing motor tasks.
Locations (3)
Shanghai Ruijin Hospital, affiliated to Shanghai Jiao Tong University, School of medicine
Shanghai, Shanghai Municipality, China
Shanghai Yang Zhi Rehabilitation Hospital
Shanghai, Songjiang, China
Changhai Hospital
Shanghai, Yangpu, China