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The Effects of Cannabis on Male Reproductive Functions
Sponsor: Kanako Hayashi
Summary
The purpose of this study is to understand the direct effects of cannabis on male reproductive functions. The investigators plan to conduct a double-blind, placebo-controlled clinical trial to examine both the chronic and acute effects of cannabis use on male reproductive functions. Specifically, the investigators will examine the dose-dependent effects of acute cannabis use on male reproductive parameters, including sperm counts, motility, morphology, and testosterone levels, as well as sperm epimutations. Participants \[cannabis users will be randomly assigned to 1) non-vaping, 2) placebo (vaping without cannabis), and 2 doses of cannabis, 3) 20 and 4) 40mg of THC in cannabis flower obtained from the NIDA drug supply\], and 5) non-cannabis users (naïve control, no cannabis or placebo exposure). Participants will provide surveys (cannabis use and sexual functioning and satisfaction etc.), peripheral blood, and semen.
Official title: The Acute and Chronic Effects of Cannabis on Reproductive Functions in Men
Key Details
Gender
MALE
Age Range
21 Years - 64 Years
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2025-04-01
Completion Date
2027-03-30
Last Updated
2025-01-03
Healthy Volunteers
Yes
Conditions
Interventions
Cannabis plant (THC 20mg)
Cannabis flower - very High THC (\>10%) / Low CBD (\<1%)
Cannabis (0%/ THC / 0% CBD)
THC (0%) / CBD (0%) - Placebo marijuana
Cannabis plant (THC 40mg)
Cannabis flower - very High THC (\>10%) / Low CBD (\<1%)
Locations (1)
Washington State University
Pullman, Washington, United States