Clinical Research Directory
Browse clinical research sites, groups, and studies.
The Role of Toll-like Receptor-4 in Periodontitis Patients With End-stage Renal Disease in a Sample of Egyptian Population
Sponsor: Ain Shams University
Summary
Chronic kidney disease (CKD) is a significant public health issue in Egypt, leading to end-stage renal disease (ESRD). ESRD patients often suffer from oral abnormalities due to the disease and medications. Periodontitis is linked to systemic diseases, including renal disease, with inflammation playing a key role. TLR4 genetic variations may influence susceptibility to CKD and periodontitis. This study investigates the association between TLR4 \[Gly/Thr (rs2149356)\] polymorphism and chronic periodontal disease in ESRD patients in Egypt.
Key Details
Gender
All
Age Range
30 Years - 60 Years
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2025-04-01
Completion Date
2025-08-01
Last Updated
2025-07-04
Healthy Volunteers
Yes
Conditions
Locations (1)
hemodialysis center at Benha University Hospital.
Al Fayyum, Faiyum Governorate, Egypt