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Management of Postoperative Discomfort in Young Children Following Dental Rehabilitation Under General Anesthesia
Sponsor: Boston University
Summary
The purpose of this study is to investigate the effectiveness of various oral analgesic regimens in minimizing post-operative pain and discomfort in young children following dental rehabilitation under general anesthesia (DRGA). In this randomized controlled trial, three analgesic regimens following DRGA in Franciscan Children's Hospital will be compared using both self-report and behavioral measures. The analgesic therapies to be investigated are ibuprofen monotherapy, alternating ibuprofen and acetaminophen dual-therapy, and combined ibuprofen and acetaminophen dual-therapy. For the purposes of this study, combined therapy is defined as the simultaneous administration of acetaminophen and ibuprofen at regular intervals, whereas alternating therapy is defined as one analgesic (acetaminophen or ibuprofen) administered within a 3 hour interval of the other.
Official title: A Comparison of Standard Dose of Ibuprofen Alone, Alternating, or Combined With Acetaminophen for the Management of Postoperative Discomfort in Young Children Following Dental Rehabilitation Under General Anesthesia
Key Details
Gender
All
Age Range
4 Years - 6 Years
Study Type
INTERVENTIONAL
Enrollment
75
Start Date
2025-04-16
Completion Date
2027-03
Last Updated
2026-04-02
Healthy Volunteers
No
Conditions
Interventions
Ibuprofen
10 mg/kg/dose of ibuprofen will be given every 6 hours for 24 hours post surgery
Acetominophen
15 mg/kg/dose of acetominophen will be given every 6 hours for 24 hours post surgery
Locations (1)
Franciscan Children's Hospital
Brighton, Massachusetts, United States