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Validation and Simplification of the Retinol Isotope Dilution Technique in Burkinabe Schoolchildren
Sponsor: Institut de Recherche en Sciences de la Sante, Burkina Faso
Summary
Two cross-sectional, repeated-pass, community-based studies will be carried out during the school year. The first study will be conducted from November to December. This period corresponds to the end of the rainy season and the end of the mango season, which is one of the main sources of vitamin A in the Orodara region. The second survey will be carried out 5 to 6 months (April-May of the following year) after data collection for the first study, corresponding to the mango season. The same schoolchildren recruited during the first phase of data collection (5 to 6 months earlier) will be the participants in the second study. The interest of this study is to use nuclear techniques to implement a strategy for the precise and accurate determination of Vitamin A status in order to reinforce existing Vitamin A interventions and policies.
Key Details
Gender
All
Age Range
7 Years - 12 Years
Study Type
OBSERVATIONAL
Enrollment
158
Start Date
2024-11-21
Completion Date
2025-06-30
Last Updated
2025-03-18
Healthy Volunteers
Yes
Conditions
Interventions
Retinol isotope dilution technique
A group of 60 school children will be recruited through a stratified sampling. To this first group of 60 school children a retinol isotope dilution (RID) test for total body store assessment will be applied. The remaining 98 school children will be recruited according to stratified sampling and divided into two groups of 49 children (females and males). To these groups of children, the modified relative dose response (MRDR) test, a qualitative measure of vitamin A status will be used to investigate the absorption of 3,4-didehydroretinyl acetate in oil.
Locations (1)
IRSS-DRO
Bobo-Dioulasso, Bobo-Dioulasso, Houet, Région Des hauts-Bassins, Burkina Faso