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Investigating the Optimal Management of Dolutegravir Resistance
Sponsor: University of Nairobi
Summary
The goal of this study is to address the gap in published data on viral suppression among people meeting the criteria for virologic failure on dolutegravir (DTG)-based ART regimens without a change in regimen. The study will also assess the emergence of DTG-associated drug-resistant mutations and their impact on viral suppression.
Official title: Investigating the Optimal Management of Dolutegravir Resistance: a Multi-country Cohort Study
Key Details
Gender
All
Age Range
1 Year - Any
Study Type
OBSERVATIONAL
Enrollment
6600
Start Date
2025-03-03
Completion Date
2026-10
Last Updated
2025-09-05
Healthy Volunteers
No
Conditions
Interventions
Continue DTG-based antiretroviral therapy
Participants will continue on DTG-based ART after enrollment for up to 12 months
Enhanced adherence counselling
Participants with VL ≥200 copies/mL will undergo enhanced adherence counselling
Locations (9)
Jaramogi Oginga Odinga Teaching and Referral Hospital
Kisumu, Kenya
Bomu Hospital
Mombasa, Kenya
Kenyatta National Hospital
Nairobi, Kenya
Butha-Buthe District Hospital
Butha-Buthe, Lesotho
Mokhotlong District Hospital
Mokhotlong, Lesotho
CS Ponta Gea
Beira, Sofala, Mozambique
CS Machava II
Maputo, Mozambique
CS Ndlavela
Maputo, Mozambique
MUHAS Clinical Trial Unit
Dar es Salaam, Tanzania