Clinical Research Directory

Inclusion Criteria: * Advanced/metastatic solid tumors other than primary lung cancer * Alk-positive or MET14 exon skipping mutation by IHC\\FISH\\NGS\\RT-PCR * Have no standard treatment after MDT discussion, or could not tolerate the standard treatment, or the patient refused the standard treatment * Adequate liver and kidney function * Adequate bone marrow function * ECOG PS 0-3 * Female subjects should not be pregnant. All human subjects should able to comply with the required protocol and follow-up procedures, and able to receive oral medications Written informed consent provided Exclusion Criteria: * Active viral, bacterial, or fungal infection detected 2 weeks before enrollment * Pregnancy or lactation * receiving medications or herbal supplements with potent inducers of CYP3A4 (at least 3 weeks prior) * Any severe or uncontrolled systemic illness, including uncontrolled Hypertension and active bleeding, any nonadherence that the investigator considered to be detrimental to study participation or adherence to the protocol, or active infections including hepatitis B, hepatitis C, and human immunodeficiency virus (HIV) * Ineligible cardiac function * Interstitial lung disease, drug-induced interstitial lung disease, previous history of radiation pneumonitis requiring steroid therapy, or any evidence of active interstitial lung disease * Lack of adequate bone marrow reserve or organ function