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The HIEnome Study: Genome Sequencing for Perinatal HIE
Sponsor: Baylor College of Medicine
Summary
Perinatal hypoxic-ischemic encephalopathy is a rare severe condition in which neonates present with encephalopathy and a clinical history suggestive of prenatal or perinatal hypoxic-ischemic injury. Emerging evidence suggests that genetic conditions are frequently identified in cases of perinatal HIE; however, it is unclear which neonates with this diagnosis warrant genetic testing. This study will offer clinical genome sequencing to neonates with HIE who are undergoing total body cooling (therapeutic hypothermia) and their parents.
Key Details
Gender
All
Age Range
0 Days - 1 Year
Study Type
INTERVENTIONAL
Enrollment
25
Start Date
2025-05-15
Completion Date
2027-06-30
Last Updated
2025-10-01
Healthy Volunteers
No
Conditions
Interventions
Genome sequencing
Neonates enrolled in this study will undergo genome sequencing with parental controls as applicable.
Locations (2)
Texas Children's Hospital
Houston, Texas, United States
Texas Children's Hospital
Houston, Texas, United States