Clinical Research Directory

Inclusion Criteria: * Compliant healthy patients who had at least one immature maxillary permanent incisor requiring nonsurgical root canal treatment. * Patients presenting with a diagnosis of pulp necrosis with chronic apical periodontitis confirmed by history, clinical, radiographic and operative examination. * Patient without previous endodontic treatment in affected tooth. Exclusion Criteria: * Patients with systemic conditions (medical, developmental or behavioral) that make routine dental treatment difficult. * Patients taking medications that can interfere with healing or hemostasis. * Patients with allergy to local anesthetics * Children who will not comply to recall program. * Teeth with extensive loss of coronal tissue that require restoration with a post * Teeth with internal or external root resorption