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NCT06763471

Measuring Single Neuron Activity in the Brain

Sponsor: University College, London

View on ClinicalTrials.gov

Summary

The SUNAN (Single Unit Neurophysiological Architecture of the Neocortex) study aims to understand how individual brain cells called neurons interact and communicate, and how the neurons can be affected in neurological disease. Using an advanced digital probe called the "Neuropixels probe," which is as thin as a human hair, the investigators can record electrical activity from individual neurons on the outmost layer of the brain (cerebral cortex). This electrical (neurophysiological) activity recording technique allows the investigators to isolate and monitor single-neuron activity from the human brain during planned neurosurgical operations in real time.

Official title: Single Unit Neurophysiological Architecture of the Neocortex (SUNAN)

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

Start Date

2025-02

Completion Date

2028-02

Last Updated

2025-01-08

Healthy Volunteers

Conditions

Neurological Diseases or Conditions

Interventions

DEVICE

Neuropixels recording intraoperatively during planned neurosurgery

The SUNAN study is a basic science study involving a procedure to record single-unit neurophysiological activity with human participants who are already undergoing a transcranial neurosurgical procedure on the brain. As part of the surgery, a region of cerebral cortex on the convexity of the brain will be: * Resected e.g., as removal of part of a tumour or epilepsy focused. Or * Transgressed as part of the surgical approach to reach a deeper target e.g., resection of a deep tumour or cavernoma. Or • Transgressed by the passage of a surgical implant e.g., a ventriculoperitoneal shunt catheter or deep brain stimulation electrode. Within this region of the brain that is going to be resected or transgressed, the research team will undertake a single-unit resolution neurophysiological recording (NR) using a digital neural probe (Neuropixels) for a maximum of 15 minutes.

1. Aged 18 years and over. 2. Documented informed consent to participate. 3. Undergoing a transcranial neurosurgical procedure at the National Hospital for Neurology and Neurosurgery (NHNN) in which part of the cerebral cortex will be: * Resected e.g., as removal of part of a tumour or epilepsy focused. Or * Transgressed as part of the surgical approach to reach a deeper target e.g., resection of a deep tumour or cavernoma. Or • Transgressed by the passage of a surgical implant e.g., a ventriculoperitoneal shunt catheter or deep brain stimulation electrode. 4. Surgery felt to be technically suitable for the neurophysiological recording technique by the Chief Investigator and responsible Consultant Neurosurgeon. For example, participants having surgery in an unusual position may present problems for the neurophysiological recording step. Exclusion Criteria: 1. Participants who lack the capacity to give informed consent. 2. Participants who are pregnant or breast feeding at the time of surgery. 3. Participants deemed to be unsuitable for recruitment to the study by the responsible Consultant Neurosurgeon. If in the view of the treating consultant involvement in the study would compromise the patient's surgery or present an unacceptable risk to them, they will not be recruited to the study. For example, if the participant does not meet the standard of care preoperative checks. 4. Concern from the Consultant Neurosurgeon or treating Anaesthetist that there would be an unreasonable burden on the patient to participate in the study. For example, risk due to increased length of anaesthetic time. 5. For participants requiring anaesthesia for their pre-planned brain surgery, an American Society of Anaesthesiologists (ASA) physical status classification system score of 4 and higher. 6. Participants unable to understand English sufficiently well to read the patient facing documents and consent in English. 7. Participants not undergoing their treatment through National Health Service (NHS) care (i.e. private patients are excluded).