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Oral Nicotine Pouches Versus Nicotine Replacement Therapy to Reduce Cigarette Use for Smokers in Rural Appalachia
Sponsor: Ohio State University Comprehensive Cancer Center
Summary
This clinical trial compares the use of oral nicotine pouches to nicotine replacement therapy, consisting of nicotine patches and lozenges, to reduce cigarette use in smokers living in rural Appalachia. The lung and oral cancers that plague Appalachia are fueled by cigarette smoking. Oral nicotine pouches which contain nicotine but no tobacco leaf, present a new opportunity to reduce cancer risk among Appalachian adults who smoke. Oral nicotine pouches and nicotine replacement therapy may work well to reduce cigarette use for smokers in rural Appalachia.
Official title: Testing Oral Nicotine Pouches to Reduce Smoking-Related Cancer in Rural Appalachia
Key Details
Gender
All
Age Range
21 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1000
Start Date
2025-06-13
Completion Date
2028-12-31
Last Updated
2025-06-22
Healthy Volunteers
Yes
Conditions
Interventions
Carbon Monoxide Measurement
Undergo carbon monoxide measurement
Nicotine Lozenge
Use nicotine lozenge
Oral Nicotine Pouch
Use oral nicotine pouch
Nicotine Patch
Use nicotine patch
Survey Administration
measurements; data gathering
Check-in Phone Calls
Check-in phone calls to study participants
Locations (1)
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States