Clinical Research Directory

Inclusion Criteria: * The inclusion criteria for the study are as follows: 1. clinical diagnosis of acute Neuromyelitis Optica Spectrum Disorders (NMOSD) 2. Age and Gender: Participants must be between 18 and 65 years old, inclusive, with no gender restrictions. 3. Serological Marker: Participants must test positive for AQP4-IgG using the cell-based assay (CBA) method. 4. Understanding and Consent: Participants or their legal representatives must be able to understand the study's purpose, demonstrate sufficient compliance with the study protocol, and sign the informed consent form. Exclusion Criteria: 1. Women who are pregnant or breastfeeding. 2. Participants who cannot establish peripheral or central venous access, or have a history of allergic reactions to plasmapheresis. 3. Participants with contraindications to intravenous methylprednisolone treatment. 4. Participants who have used monoclonal antibodies in the last 6 months, or FcRn antagonists in the last 3 months. 5. Participants who must use ACE inhibitors (ACEI) within 1 week before the start of treatment or during the study, and cannot discontinue their use. 6. Severe Bleeding or Bleeding Disorders 7. Severe Heart Failure 8. Severe Infections